�A University of North Carolina at Chapel Hill spin-off company has been awarded a $2 one thousand thousand grant to commercialize a new engineering to improve radiation discussion of prostate cancer.
The grant from the National Cancer Institute, as part of its Small Business Innovation Research programme, will enable Morphormics Inc. to market its proprietorship technology for rapidly constructing anatomical "roadmaps" of individual patients.
"These roadmaps are critical navigational aIDS that serve physicians keep a radiation therapy beam focussed on the tumor, while at the same time avoiding nearby parts of the body that could be harmed by radiation exposure," aforementioned Edward L. Chaney, Ph.D., Morphormics' vice president of technology, prof in the School of Medicine's section of radiation oncology, and member of the UNC Lineberger Comprehensive Cancer Center.
As part of pre-treatment planning, radiation oncologists build the three-dimensional anatomic roadmaps of their patients by excluding sensitive organs and other anatomical structures from the medical images that are used to guide discourse. Currently, the process for creating such maps is both time-consuming and expensive, Chaney said.
Morphormics' solution is based on "m-reps," which are mathematical representations of anatomical structures. M-reps were conceived of and developed by UNC's Medical Image Display and Analysis inquiry group (MIDAG) with federal funding. The Morphormics system uses m-reps to automatically "extract" the prostate, bladder, seminal vesicles, a portion of the rectum and the femoral heads from 3-D medical images to form the anatomical roadmaps.
"This system will dramatically better efficiency, reduce costs and increase the reliability of treatment planning and delivery decisions," Chaney said. "This grant is an important step towards bringing these UNC cancer research developments to help patients with prostate crab everywhere."
Morphormics, besides known as Mx, was founded in 2001 by Chaney and fellow UNC professors Stephen M. Pizer, Ph.D., Kenan Professor in the departments of computing device science and radiation oncology, and Sarang Joshi, D.Sc., who at the time was an assistant professor at UNC and is now at the University of Utah.
Morphormics' formation was also facilitated by Nick England, president of 3rdTech, a business incubator company. England founded 3rdTech specifically to brood spin-offs that commercialize engineering developed in the estimator science department in UNC's College of Arts and Sciences.
Pizer and Joshi ar consultants under the Small Business Innovation Research project and England provides resources and counsel for ship's company development.
All of the cerebral property on which the Morphormics system is based was developed at UNC and is licensed to Morphormics.
Click here to see an image created victimisation Morphormics' technology.
Source: Patric Lane
University of North Carolina at Chapel Hill
More info
Tuesday, 9 September 2008
Saturday, 30 August 2008
Psoriasis: More Than Skin Deep
�Psoriasis is a inveterate disease of the immune system that affects the skin. As many as 7.5 million Americans suffer from psoriasis, according to the National Institutes of Health. Unlike early diseases of the immune system which affect women more oftentimes than work force, psoriasis occurs about evenly in work force and women.
Psoriasis is non contagious and cannot be spread from person to person. There are basketball team known forms of the disease. "The most common form, plaque psoriasis, appears as raised, red patches or lesions covered with a silver white buildup of dead skin cells called scale," explains Bruce F. Bebo, Jr., Ph.D., director of research and medical programs at the National Psoriasis Foundation in Portland, Ore.
For some people, psoriasis can buoy be a nuisance, for others, it can be debilitating. The symptoms motley from person to somebody and tin include:
-- Red, itchy patches of skin that are covered with silver-colored scales.
-- Dry, nettled or cracked skin that can bleed when scratched.
-- Disorders of the fingernails or toenails including thickened or ridged nails. The nails can become brittle and in some cases, detach from the nail beds.
Most cases of psoriasis wax and wane and include flare-ups which last for a few weeks to months. Some people will go into remission for months to years. But in about cases, the psoriasis volition reappear.
Psoriasis bathroom also principal to psoriatic arthritis, which can suit pain and swelling in the joints. Roughly one-tenth to one-third of people with psoriasis will likewise have psoriatic arthritis, according to the National Psoriasis Foundation. Psoriatic arthritis throne lead to joint wearing and fix in the way of daily functioning.
Although it affects both genders equally, recent studies designate that there may be a racial or cultural link. "It seems that psoriasis is most common in Caucasians and slightly less vernacular in African Americans. Worldwide, psoriasis is most common in Scandinavia and other parts of northern Europe. It appears to be far less common among Asians and is rare in Native Americans," Bebo points out.
Research has identified some differences between the sexes in psoriasis related to to smoking and alcohol consumption.
Smoking increases the endangerment of development psoriasis and can make the disease more severe, especially in women, merely the risk of infection goes down if you stop smoking. Alcohol appears to move psoriasis in men more strongly than in women. Researchers don't know why, but alcoholic beverage consumption appears to be a danger factor for psoriasis in men just not women and it may lower treatment reaction in men.
The cause of psoriasis isn't fully gain. The disease is related to a malfunction in the resistant system, which results in T-cells assaultive healthy skin cells. What triggers the T-cell malfunction isn't known, but many researchers cite genetic and environmental factors as possibilities. The to the highest degree noteworthy jeopardy factor for psoriasis is family history. Roughly 30 percent of people with psoriasis have a close relative with the disease.
Diagnosing psoriasis is often done in a doctor's place. "No particular blood tests or diagnostic tools exist to diagnose psoriasis. The physician or other health care supplier usually examines the affected skin and decides if it is from psoriasis. Less ofttimes, the physician examines a piece of skin (biopsy) under the microscope," explains Bebo.
There are several therapies for psoriasis available to patients, which focus on reducing peel inflammation and plaque formation. Looking to the future, there are "a number of new treatments in the psoriasis pipeline," Bebo said, which may help reduce the burden of this chronic and disabling disease. The types of treatments in development include biologics, monoclonal antibody antibodies and immune system modulators.
Women with psoriasis world Health Organization are meaning, may become pregnant, or are breastfeeding should talk about carefully with their doctors their treatment options, as some treatments for psoriasis may crusade birth defects. There is, however, some good news for pregnant women. Research has shown that hormonal changes during pregnancy english hawthorn lead to improvements in psoriasis symptoms, providing impermanent relief.
August is Psoriasis Awareness Month. For more info, you can visit the National Psoriasis Foundation on-line at hypertext transfer protocol://www.psoriasis.org.
Society for Women's Health Research (SWHR)
1025 Connecticut Ave. NW, Ste. 701
Washington, DC 20036
United States
http://www.womenshealthresearch.org
More information
Psoriasis is non contagious and cannot be spread from person to person. There are basketball team known forms of the disease. "The most common form, plaque psoriasis, appears as raised, red patches or lesions covered with a silver white buildup of dead skin cells called scale," explains Bruce F. Bebo, Jr., Ph.D., director of research and medical programs at the National Psoriasis Foundation in Portland, Ore.
For some people, psoriasis can buoy be a nuisance, for others, it can be debilitating. The symptoms motley from person to somebody and tin include:
-- Red, itchy patches of skin that are covered with silver-colored scales.
-- Dry, nettled or cracked skin that can bleed when scratched.
-- Disorders of the fingernails or toenails including thickened or ridged nails. The nails can become brittle and in some cases, detach from the nail beds.
Most cases of psoriasis wax and wane and include flare-ups which last for a few weeks to months. Some people will go into remission for months to years. But in about cases, the psoriasis volition reappear.
Psoriasis bathroom also principal to psoriatic arthritis, which can suit pain and swelling in the joints. Roughly one-tenth to one-third of people with psoriasis will likewise have psoriatic arthritis, according to the National Psoriasis Foundation. Psoriatic arthritis throne lead to joint wearing and fix in the way of daily functioning.
Although it affects both genders equally, recent studies designate that there may be a racial or cultural link. "It seems that psoriasis is most common in Caucasians and slightly less vernacular in African Americans. Worldwide, psoriasis is most common in Scandinavia and other parts of northern Europe. It appears to be far less common among Asians and is rare in Native Americans," Bebo points out.
Research has identified some differences between the sexes in psoriasis related to to smoking and alcohol consumption.
Smoking increases the endangerment of development psoriasis and can make the disease more severe, especially in women, merely the risk of infection goes down if you stop smoking. Alcohol appears to move psoriasis in men more strongly than in women. Researchers don't know why, but alcoholic beverage consumption appears to be a danger factor for psoriasis in men just not women and it may lower treatment reaction in men.
The cause of psoriasis isn't fully gain. The disease is related to a malfunction in the resistant system, which results in T-cells assaultive healthy skin cells. What triggers the T-cell malfunction isn't known, but many researchers cite genetic and environmental factors as possibilities. The to the highest degree noteworthy jeopardy factor for psoriasis is family history. Roughly 30 percent of people with psoriasis have a close relative with the disease.
Diagnosing psoriasis is often done in a doctor's place. "No particular blood tests or diagnostic tools exist to diagnose psoriasis. The physician or other health care supplier usually examines the affected skin and decides if it is from psoriasis. Less ofttimes, the physician examines a piece of skin (biopsy) under the microscope," explains Bebo.
There are several therapies for psoriasis available to patients, which focus on reducing peel inflammation and plaque formation. Looking to the future, there are "a number of new treatments in the psoriasis pipeline," Bebo said, which may help reduce the burden of this chronic and disabling disease. The types of treatments in development include biologics, monoclonal antibody antibodies and immune system modulators.
Women with psoriasis world Health Organization are meaning, may become pregnant, or are breastfeeding should talk about carefully with their doctors their treatment options, as some treatments for psoriasis may crusade birth defects. There is, however, some good news for pregnant women. Research has shown that hormonal changes during pregnancy english hawthorn lead to improvements in psoriasis symptoms, providing impermanent relief.
August is Psoriasis Awareness Month. For more info, you can visit the National Psoriasis Foundation on-line at hypertext transfer protocol://www.psoriasis.org.
Society for Women's Health Research (SWHR)
1025 Connecticut Ave. NW, Ste. 701
Washington, DC 20036
United States
http://www.womenshealthresearch.org
More information
Wednesday, 20 August 2008
Multi-Tasking Molecule Holds Key To Allergic Reactions
�As the summer approaches most of us exuberate, reach for the sunblock and capitulum outdoors. But an ever-growing number of people give for tissue instead as pollen leaves eyes tearing, noses linear and hard drink dwindling. Hay fever is just one of a host of hypersensitivity supersensitive diseases that cause agony worldwide and others, such as severe reactions to bee stings or feeding peanuts, can be more serious and even fatal.
Now, scientists at the Salk Institute for Biological Studies give uncovered the molecular mechanisms behind such allergies, insight they hope will lead to new therapies, both to diaphragm the summertime sneezing and treat more severe allergic responses.
"These results may allow us to prepare acute inhibitors of hypersensitized reactions that do non have the side-effects of current treatments such as drowsiness," says Inder Verma, Ph.D., a professor in the Laboratory of Genetics and senior author of the work published in the August 8 issue of Cell.
When our bodies come across an allergen (such as pollen), specialised cells called mast cells undergo "de-granulation", during which they tone ending the chemic histamine. Histamine in turn causes fluid to build up in the surrounding tissue. When this litigate is working normally it offers shelter against the allergen merely in people with allergic diseases, de-granulation can fall out throughout the body, stellar to severe inflammation and in the worst cases, anaphylactic shock and death.
And allergies are a growing trouble the domain over. "One out of three Japanese people suffer from allergies," says post doc researcher Kotaro Suzuki, Ph.D., who lED the stream study.
During de-granulation, histamine is bundled into membrane bound sacks called vesicles, which then transport it to the cell surface. When the vesicles strain the open they fuse with the outer membrane of the cell, spilling their table of contents into the extra-cellular space in a process known as exocytosis. To forestall this process from going overboard the scientists kickoff had to understand how de-granulation is regulated.
Their hunch was that the allergic reaction would postulate NF-?B, a protein establish in the nucleus that regulates factor expression and was already known to be involved in early types of immune reply. To investigate this hypothesis they focused on the role of IKK2, a protein kinase, which is essential for NF-?B activation.
To return mast cells that were free of IKK2, the researchers transplanted mice that had no mast cells of their own with either normal mast cells or mast cells that lacked IKK2. Strikingly, mice with mast cells wanting IKK2 had reduced allergic reactions. The researchers fictitious that the lowered response was due to reduced NF-?B, only to their surprise, inactivating NF-?B signaling alone did not have the same effect. "That was one of the first clues that IKK2 had other roles to play," says Verma.
"IKK2 knock out mast cells couldn't firing enough histamine," added Suzuki 'but we still didn't know the molecular mechanisms." What they did get laid already was that de-granulation requires a collection of proteins - known as the SNARE complex - to tack at the cell earth's surface.
Suzuki and Verma victimized biochemical analysis to show that when an allergen is introduce, IKK2 binds to and activates unmatchable particular SNARE component called SNAP-23. Without IKK2, SNAP-23 is missing from the SNARE complex and conversely, when SNAP-23 is for good activated, removing IKK2 no longer impairs de-granulation. "This is the first major feather on the cap of IKK2 in addition to NF-?B," says Verma.
But IKK2's role in the hypersensitised response does not catch there - it multi-tasks. After the rapid "early phase" de-granulation response, mast cells undergo a "late-phase" reaction during which certain genes ar turned on to help fight the allergen. Suzuki and Verma showed that the late-phase response as well requires IKK2, but that this metre it functions by its more usual route - via NF-?B.
The Salk researchers ar now examination inhibitors of IKK2 as acute treatment for supersensitive reactions. Unlike anti-histamines, which are currently used to combat allergies, IKK2 inhibitors would have the added benefit of reducing both the early and late phase supersensitive responses.
And the newly discovered character for IKK2's may not be limited to allergic reactions. Many fundamental processes in our bodies involve exocytosis, ranging from secretion of insulin in the pancreas to synaptic transmitting, the process by which signals ar passed from one nervus cell to another. If IKK2 is involved in these processes it may have a role in other pathologies such as diabetes and nervous system diseases.
The Salk Institute for Biological Studies in La Jolla, California, is an main nonprofit organisation dedicated to fundamental discoveries in the life sciences, the improvement of human health and the training of succeeding generations of researchers. Jonas Salk, M.D., whose polio vaccine all but eradicated the incapacitating disease acute anterior poliomyelitis in 1955, opened the Institute in 1965 with a endowment of country from the City of San Diego and the financial living of the March of Dimes.
Salk Institute
More info
Now, scientists at the Salk Institute for Biological Studies give uncovered the molecular mechanisms behind such allergies, insight they hope will lead to new therapies, both to diaphragm the summertime sneezing and treat more severe allergic responses.
"These results may allow us to prepare acute inhibitors of hypersensitized reactions that do non have the side-effects of current treatments such as drowsiness," says Inder Verma, Ph.D., a professor in the Laboratory of Genetics and senior author of the work published in the August 8 issue of Cell.
When our bodies come across an allergen (such as pollen), specialised cells called mast cells undergo "de-granulation", during which they tone ending the chemic histamine. Histamine in turn causes fluid to build up in the surrounding tissue. When this litigate is working normally it offers shelter against the allergen merely in people with allergic diseases, de-granulation can fall out throughout the body, stellar to severe inflammation and in the worst cases, anaphylactic shock and death.
And allergies are a growing trouble the domain over. "One out of three Japanese people suffer from allergies," says post doc researcher Kotaro Suzuki, Ph.D., who lED the stream study.
During de-granulation, histamine is bundled into membrane bound sacks called vesicles, which then transport it to the cell surface. When the vesicles strain the open they fuse with the outer membrane of the cell, spilling their table of contents into the extra-cellular space in a process known as exocytosis. To forestall this process from going overboard the scientists kickoff had to understand how de-granulation is regulated.
Their hunch was that the allergic reaction would postulate NF-?B, a protein establish in the nucleus that regulates factor expression and was already known to be involved in early types of immune reply. To investigate this hypothesis they focused on the role of IKK2, a protein kinase, which is essential for NF-?B activation.
To return mast cells that were free of IKK2, the researchers transplanted mice that had no mast cells of their own with either normal mast cells or mast cells that lacked IKK2. Strikingly, mice with mast cells wanting IKK2 had reduced allergic reactions. The researchers fictitious that the lowered response was due to reduced NF-?B, only to their surprise, inactivating NF-?B signaling alone did not have the same effect. "That was one of the first clues that IKK2 had other roles to play," says Verma.
"IKK2 knock out mast cells couldn't firing enough histamine," added Suzuki 'but we still didn't know the molecular mechanisms." What they did get laid already was that de-granulation requires a collection of proteins - known as the SNARE complex - to tack at the cell earth's surface.
Suzuki and Verma victimized biochemical analysis to show that when an allergen is introduce, IKK2 binds to and activates unmatchable particular SNARE component called SNAP-23. Without IKK2, SNAP-23 is missing from the SNARE complex and conversely, when SNAP-23 is for good activated, removing IKK2 no longer impairs de-granulation. "This is the first major feather on the cap of IKK2 in addition to NF-?B," says Verma.
But IKK2's role in the hypersensitised response does not catch there - it multi-tasks. After the rapid "early phase" de-granulation response, mast cells undergo a "late-phase" reaction during which certain genes ar turned on to help fight the allergen. Suzuki and Verma showed that the late-phase response as well requires IKK2, but that this metre it functions by its more usual route - via NF-?B.
The Salk researchers ar now examination inhibitors of IKK2 as acute treatment for supersensitive reactions. Unlike anti-histamines, which are currently used to combat allergies, IKK2 inhibitors would have the added benefit of reducing both the early and late phase supersensitive responses.
And the newly discovered character for IKK2's may not be limited to allergic reactions. Many fundamental processes in our bodies involve exocytosis, ranging from secretion of insulin in the pancreas to synaptic transmitting, the process by which signals ar passed from one nervus cell to another. If IKK2 is involved in these processes it may have a role in other pathologies such as diabetes and nervous system diseases.
The Salk Institute for Biological Studies in La Jolla, California, is an main nonprofit organisation dedicated to fundamental discoveries in the life sciences, the improvement of human health and the training of succeeding generations of researchers. Jonas Salk, M.D., whose polio vaccine all but eradicated the incapacitating disease acute anterior poliomyelitis in 1955, opened the Institute in 1965 with a endowment of country from the City of San Diego and the financial living of the March of Dimes.
Salk Institute
More info
Sunday, 10 August 2008
A conversation with Kid Rock
To listen to the interview on NOLA radio, click here.
Riding high on the timely hit "All Summer Long, " Kid Rock launches the "Rock 'n ' Rebels" tour on Friday, Aug. 8 at the New Orleans Arena with co-headliner Lynyrd Skynyrd, special guest Joseph "Rev Run" Simmons of Run-DMC and young blues-rock triple Back Door Slam.
Before heading to New Orleans for rehearsals, Rock called from the punt porch of his spreadhead outside Detroit. Early in our conversation, he hoped to not "say anything too unintelligent." That's up to you, I replied.
He laughed: "That's the problem."
With that, Rock held forth on the origins of his song "New Orleans, " the fame of his "trash king" buddy Sidney Torres and why you won't see Radiohead in strip clubs.
You were on vacation last week. Where does Kid Rock go on vacation?
A friend of mine gets a racing yacht in the south of France every year, so we went to Italy. I was going to stay dwelling house, then I was talking to Rev Run around how well "All Summer Long" has done in Europe. It's my first No. 1 single in Europe. He's like, "What are you doing? Go celebrate in Europe where your record is No. 1." So I took my brother and we had a good time.
People may think, "Why does Kid Rock need a vacation? He sings close to 'taking strippers out for breakfast' " Your normal life seems vacation-like.
(laughs) It's that old locution, "I motivation a vacation from my vacation."
There's a synergy 'tween you and Lynyrd Skynyrd. You share a direction company and you sample distribution "Sweet Home Alabama" in "All Summer Long." And for a Detroit boy, you sure have a fondness for the Rebel flag.
I feature a warmheartedness for non being politically correct. That's what it boils down to. Anything PC, number me out. I'm so tired of it. I think most people are tired of the far left and the far right. Our country has been distorted, and we don't get anything done, because there's too many extremists.
Take me and Rev Run. We're best friends, our kids are cousins. I've voted Republican most of my life, he's voted Democrat. You canful count the differences. But our friendly relationship and wHO we ar as people is more important than any of that.
That's what makes up the good of America. It doesn't matter which side of the fence you're on. Are you too extreme, or are you inactive into the basic foundations of this country and its people? We're distorted by all these freaks. So anything I can buoy do unpolitically correct, I'm down. It doesn't take me a bad person. I know exactly world Health Organization I am and I won't be defined by any symbolic representation. I'll do everything to break downward those barriers. And it's kind of fun.
You limit yourself on your albums. Your current "Rock 'n ' Roll Jesus" is evenly rent between your nobler instincts -- "Roll On, " "Amen" -- and your more primal instincts, e.g. "So Hott" and "Sugar." Is that an apt description of your deuce competing sides?
Absolutely. That's how I alive my life. People connect with the music what I connected with music when I was danton True Young. Bands like Lynyrd Skynyrd or Run-DMC or Bob Seger . . . when I heard those songs, I really believed it was them. They were writing some the things they knew and wHO they were. When I saw it live it touched me. That's missing from so much music nowadays. There's four songwriters, two producers, a stylist . . .so often smoke and mirrors tortuous before you get to the heart and soul of an artist. That's why a lot of people get in touch with what I'm doing.
Mashing up "Sweet Home Alabama" and Warren Zevon's "Werewolves of London" into a summer hymn seems obvious, but no one else thought of it.
I'm sure people aren't thinking about it as deep or as wily as I'd like them to think I am. Mash-ups are huge; rappers have been rapping over them for years. For that matter, people from the Rolling Stones on down have been adoption riffs, whether it be Motown or anything else. What I did was blatantly come out and take this, put some original beats to it, and wrote an original melody and lyric on top of it. We (Rock, Skynyrd, Zevon's estate) split the song's publication. Everyone agreed that it's something old and something new.
Did you audition the girls for the "All Summer Long" video?
No. I've never gotten into that. People think I'm kayoed getting hos for the videos, that I'm matchless of those guys wHO hangs about like, "Hey, you want to be in my video?" I don't think I've of all time said that in my life. I've never been to an audition, I've never watched the tapes. It's a big misconception. (But) if I've had a admirer ask to be it in, sure.
"All Summer Long" may get introduced many Europeans to "Sweet Home Alabama."
I mentation that. But years agone, I was getting quick to act "Cowboy" at this vast festival in Germany. I started riffing off "Sweet Home Alabama, " people started clapping and they wouldn't stop. So I played it. There was 80,000 Germans singing along; you could hear the accents.
Pop medicine has become watered-down rap music. To hear something that's blues-based is a breath of fresh air, especially in Europe. You step foot anywhere over there, the only thing you hear is, "Oof-oof-oof" (Rock impersonates a techno beat). It's enough to drive you batty.
When you came up with the title "Rock 'n ' Roll Jesus, " you probably weren't thinking about Sebastian Bach in "Jesus Christ Superstar."
(Laughs) No, sir.
Is "New Orleans" your Hurricane Katrina tune?
I started writing that before Katrina. That's an old song that I'd been working on. I didn't know what it was about; I only knew it had that groove, and I could hear the horns in my head. New Orleans is one of my favorite muscae volitantes in the world, and that's never changed. After Katrina, I kept penning it. (Outlaw country songster) David Allan Coe helped me out with the lyrics. He gave me "le bons temps rouler" and a lot of the New Orleans stuff that I wasn't educated on.
After Katrina, I thought, "I wonder if Fats Domino is OK? Did somebody pay back Fats?" I'd been by his house. So I started writing the strain kind of about him, in a metaphoric agency. God bless his person. He's one of my favorites ever.
The lyrics of "New Orleans" contain some obvious images, like "jambalaya" and "crawfish pie, " which refer to Hank Williams' "Jambalaya." Who came up with the more insider "hey pocky way" line?
That was me. The Meters . . . that's been one of my favourite tunes eternally. That's always a (tour) bus pet. When you're going to kick the party into high geartrain, I don't grab for the Radiohead CD. I grab the Meters' "Hey Pocky Way."
You don't hear a destiny of Radiohead at strip clubs.
None. (Radiohead singer) Thom Yorke said the other night onstage in Indianapolis, "If you're looking for Kid Rock, he's non here." Which I thought was kind of suspicious. I've been poking at him for years, in a fun way. He finally took the twit. (laughs) It's all in fun. I've got naught against them or anybody.
Your history with New Orleans includes an ctive piece of writing session ahead "Devil Without a Cause."
It was an unproductive school term. We really got sued by me saying that I wrote "Somebody's Gotta Feel This" in New Orleans. Some idiot aforesaid it was his sung. It got thrown out eventually, merely it cost me $70,000 and a band of red tape to make the case go away. This happens all the time. Nobody of all time wins demur the scumbag lawyers with agendas.
So you've been to New Orleans since Katrina?
Oh, yeah. A lot of good citizenry are doing so practically stuff grim there, my buddy Sidney Torres (head honcho of SDT Waste and Debris), and Brad Pitt. The city's come a long way, and God hallow it.
I hadn't heard around you taking a cataclysm tour. You were very low-key around it.
Unless it's going to bring some money in and help people, there's no reason for me to let people recognise, "Look, I'm concerned." I don't take those opportunities for press.
Do you know Sidney Torres through Lenny Kravitz?
I know him through a crony of mine, Rande Gerber (founder of Los Angeles' famed Sky Bar and Whiskey Blue in the W Hotel on Poydras Street). Sidney's always been so gracious to us. His whole family, his mom, his whole crew. The scrap king. New Orleans is so fortunate to consume a family like that.
Sidney told me a story about horseback riding around Bourbon Street with Lenny Kravitz. People accepted Torres and not Kravitz.
The same thing with me! We were cruising around in unmatchable of those four-wheel Kawasaki mule things, and it's, "Sidney! Sidney!" I'm like, "Hold on a second base. Go back and let me get my hat."
You recently pleaded no contest to simple battery later a fight at an Atlanta-area Waffle House. Do you design to steer clear of Waffle Houses during your New Orleans adventures?
(laughs) I embrace the Waffle House. In Atlanta, I went back and signed autographs at the Waffle House and we raised about $15,000 for a shelter that helps homeless families make back on their feet. So we flipped it around and turned it into something positive, because it was so slow. Of grade when you're Kid Rock and something dumb like that happens, you get a suit for $4 million.
Will the "Rock 'n ' Rebels" show be your common marathon?
It's really cut down a little bit. That many hours of medicine is a lot for people. Especially when you get a Skynyrd and Kid Rock crowd. They like to drink. There will be some alcohol consumed, and some tailgating. We want to make sure everyone has a good time. We precisely give 'em enough, and all the stuff they want to hear.
I interviewed your sidekick Hank Williams Jr. last year. He's proud to hold the record for beer gross revenue at several arenas.
I say the same thing, and so does Skynyrd. We're going to have to run the numbers. (laughs)
So does your show lineament women in cages again?
No. Next year I'm planning on the whole fiasco -- fireworks, girls, the whole nine-spot. That's my plan correct now. (For this hitch) with the 11-piece band, I wanted to take away it back to the music, which has worked out great. I've gotten the best reviews of my life.
Can we require to try "New Orleans" at the New Orleans Arena?
We're going to practice it all week. So I would say yes.
Will the Skynyrd guys join you for "All Summer Long"?
We won't know until (tonight). I don't want to create them hang out whatever longer than they consume to, merely if they're around and want to play . . . They can play with me on whatever song they'd like to.
_________________________
ROCK 'N ' REBELS TOUR
Featuring: Kid Rock and Lynyrd Skynyrd plus Rev Run and Back Door Slam
When: Tonight, Aug. 8, 6:30.
Where: New Orleans Arena, 1501 Girod St.
Tickets: $30 to $195 plus service charges
More info
Tuesday, 1 July 2008
Love Guru -- Worst Film Of The Year?
Mike Myers's The Love Guru , which is being released on Friday, is receiving so many blistering early reviews that Los Angeles Times writer Tom O'Neil, who tracks films up for major awards in his column "Gold Derby," is predicting that the film may be a shoo-in for the Razzie for worst film of the year. For example, Moira Macdonald in the Seattle Times calls it "preadolescent humor with a few sitars thrown in." But Kirk Honeycutt in the Hollywood Reporter observes that Guru will have competition for the worst-film title from Get Smart, which also opens on Friday. Honeycutt concludes: "Quite possibly Love Guru will out-awful Get Smart."
See Also
See Also
Thursday, 19 June 2008
Sex And The City - Crystal Skull Unbreakable Overseas
It has fallen short of the record worldwide box office set last year by Pirates
of the Caribbean: At World's End, but Paramount's Indiana Jones and the Kingdom
of the Crystal Skull has now taken in $266 million overseas, the studio said
Monday. The figure is about $30 million short of that set by Pirates during the
same period a year ago. Over the past weekend, the latest Indiana Jones sequel
took in $71.5 million in 60 countries. Continuing to surprise box office analysts
which predicted light business for it overseas, Sex and the City raked in an impressive
$39.2 million during its opening in 13 countries ($18.3 million coming from the U.K.).
03/06/2008
See Also
Thursday, 12 June 2008
Rock 'n roll legend Bo Diddley dies
Rock 'n' roll pioneer Bo Diddley, who banged out hit songs powered by the relentless "Bo Diddley beat" that influenced rockers from Buddy Holly to U2, has died at the age of 79.
Friday, 6 June 2008
Amy Winehouse - Amy Winehouse To Make Catwalk Debut
AMY WINEHOUSE could be making her modelling debut at London Fashion Week, if designer Julian McDonald has his way.
Reports claim that the fashion guru thinks Amy has "great style", with the Daily Star quoting him as saying: "She's an amazing talent, isn't she? She's unique."
However, these views are not echoed in all fashionable circles, with another expert telling the publication that they think Amy often looks "a mess".
"She goes for a rework of the 50s look, but when she's out of it, she looks terrible," they added.
Every year McDonald chooses a high-profile woman to wear the top gown in his collection; previously the honour has gone to supermodel NAOMI CAMPBELL and PARIS HILTON.
London Fashion Week takes place in September.
Earlier this year, fashion house Fendi chose Amy to entertain the crowds at its Paris Fashion Week show, with Karl Lagerfeld himself selecting the songstress.
She also sang at the Louis Vuitton show, for a reported £500,000 fee.
14/05/2008 14:41:59
See Also
Thursday, 29 May 2008
PBS Kicks Off a 'Get Up and Go Summer Road Trip' for Kids With an Exclusive Music Video Featuring Music by They Might Be Giants
PBSParents.org Features More Health Resources and Activities in
"Keeping Kids Fit and Healthy"
ARLINGTON, Va., May 14 /PRNewswire-USNewswire/ -- This summer, PBS KIDS
and PBS KIDS GO! invite children on a virtual road trip with a destination
all about being engaged and healthy. Beginning June 2nd, kids can fuel
their minds and bodies with health-themed episodes and online activities,
learning how their favorite character role models in ten different series
live healthy and smart. Kicking off the trip with some new tunes, Arthur,
WORDGIRL's Captain Huggyface and others join in an exclusive new music
video entitled "Get Up and Go" featuring music by famed rock band, THEY
MIGHT BE GIANTS. And with parents at the wheel, PBSParents.org is
supporting their role with more popular health content and resources around
their child's well-being and development.
"PBS KIDS is committed to supporting the whole child -- cognitive,
emotional, social and physical. Helping kids and families embrace a healthy
lifestyle is not just a one-time message; it's a lifelong journey," said
Lesli Rotenberg, Senior Vice President, Children's Media, PBS. "Parents
trust PBS KIDS to guide their children as they explore how to live healthy
and active lives."
Throughout the summer, pbskidsgo.org will offer downloadable content,
games and printable activities and dances for early elementary school kids
through the "Get GOing!" and "Smart Food" links on the Web site. For
preschoolers, the interactive story board -- Dot's Story Factory -- on
pbskids.org will encourage children to express and share how to be healthy.
Ten of the stories from Dot's Story Factory will air on television during
the PBS KIDS preschool destination, home to the #1 show CURIOUS GEORGE, and
other favorites, CLIFFORD THE BIG RED DOG, SUPER WHY! and DRAGON TALES.
On-air, children will embark on a virtual road trip of health-related
episodes, visiting characters from ten series to learn how they live
healthy. A detailed grid outlining episode descriptions, airdates and
online content is also available upon request.
And since no road trip would be complete without music, THEY MIGHT BE
GIANTS -- along with Arthur, Ruff Ruffman, the CYBERCHASE gang and others
-- turn up the volume to "Get Up and Go." A downloadable extended version
of the music video will be available at pbskidsgo.org, accompanied with a
printable and customizable dance sequence. The extended version will also
play in movie theaters across the country as part of a partnership with
Kidtoons, an organization that arranges weekend G-rated movie screenings
for kids and their parents.
To support parents who seek information and resources to help steer
their children towards success and well-being, PBS Parents (pbsparents.org)
is launching a new section focused on children's health titled, "Keeping
Kids Healthy and Fit." Topics and discussions will range from winning over
picky eaters and choosing healthy snacks to book suggestions and fitness
games.
For nearly 40 years, PBS' children's service has supported the
well-being of the whole child -- cognitive, emotional, social and physical.
In response to the dramatic predictions around children's health and
longevity tied to obesity, PBS KIDS launched a children's health initiative
to strengthen existing health-related content and resources in December
2007. PBS convened a group of health advisors including public television
and Web producers; PBS member stations; community and education partners;
experts in children's media, development, health and nutrition; and others,
to provide strategic counsel and build upon PBS KIDS' legacy and assets.
The summer road trip, leveraging PBS KIDS' library and characters that
reinforce the importance of good nutrition and physical activity, is an
example of the many assets. A project that would support a cohesive
grassroots campaign to build sustainable healthy communities is in
development.
PBS KIDS first kicked off a content line-up dedicated to inspiring
children to live healthy lives with PBS KIDS and Sesame Workshop's Happy
Healthy Summer in 2005, and continues to model healthy behaviors throughout
the series year-round. PBSTeachers.org provides year-round access to over
900 standards-based classroom resources and 700 book and Web site
recommendations related to health and fitness.
PBS KIDS, for preschoolers, and PBS KIDS GO! for early elementary
school kids, are committed to providing the highest quality non-commercial
content and learning environment for children across the country. Providing
age-appropriate, diverse programming for kids, PBS KIDS and PBS KIDS GO!
programs consistently earn more prestigious awards than any other broadcast
or cable network. Only PBS KIDS and PBS KIDS GO! have earned the unanimous
endorsement of parents, children, industry leaders and teachers. With
additional PBS resources to complement its programming, including PBS KIDS
online (pbskids.org), PBS KIDS GO! online (pbskidsgo.org), PBS Parents
(pbsparents.org), PBS Teachers (pbs.org/teachers), PBS KIDS Raising Readers
and literacy events across the country, PBS is providing the tools
necessary for positive child development. PBS is a nonprofit media
enterprise owned and operated by the nation's 355 public television
stations, serving more than 73 million people each week and reaching 99% of
American homes.
See Also
"Keeping Kids Fit and Healthy"
ARLINGTON, Va., May 14 /PRNewswire-USNewswire/ -- This summer, PBS KIDS
and PBS KIDS GO! invite children on a virtual road trip with a destination
all about being engaged and healthy. Beginning June 2nd, kids can fuel
their minds and bodies with health-themed episodes and online activities,
learning how their favorite character role models in ten different series
live healthy and smart. Kicking off the trip with some new tunes, Arthur,
WORDGIRL's Captain Huggyface and others join in an exclusive new music
video entitled "Get Up and Go" featuring music by famed rock band, THEY
MIGHT BE GIANTS. And with parents at the wheel, PBSParents.org is
supporting their role with more popular health content and resources around
their child's well-being and development.
"PBS KIDS is committed to supporting the whole child -- cognitive,
emotional, social and physical. Helping kids and families embrace a healthy
lifestyle is not just a one-time message; it's a lifelong journey," said
Lesli Rotenberg, Senior Vice President, Children's Media, PBS. "Parents
trust PBS KIDS to guide their children as they explore how to live healthy
and active lives."
Throughout the summer, pbskidsgo.org will offer downloadable content,
games and printable activities and dances for early elementary school kids
through the "Get GOing!" and "Smart Food" links on the Web site. For
preschoolers, the interactive story board -- Dot's Story Factory -- on
pbskids.org will encourage children to express and share how to be healthy.
Ten of the stories from Dot's Story Factory will air on television during
the PBS KIDS preschool destination, home to the #1 show CURIOUS GEORGE, and
other favorites, CLIFFORD THE BIG RED DOG, SUPER WHY! and DRAGON TALES.
On-air, children will embark on a virtual road trip of health-related
episodes, visiting characters from ten series to learn how they live
healthy. A detailed grid outlining episode descriptions, airdates and
online content is also available upon request.
And since no road trip would be complete without music, THEY MIGHT BE
GIANTS -- along with Arthur, Ruff Ruffman, the CYBERCHASE gang and others
-- turn up the volume to "Get Up and Go." A downloadable extended version
of the music video will be available at pbskidsgo.org, accompanied with a
printable and customizable dance sequence. The extended version will also
play in movie theaters across the country as part of a partnership with
Kidtoons, an organization that arranges weekend G-rated movie screenings
for kids and their parents.
To support parents who seek information and resources to help steer
their children towards success and well-being, PBS Parents (pbsparents.org)
is launching a new section focused on children's health titled, "Keeping
Kids Healthy and Fit." Topics and discussions will range from winning over
picky eaters and choosing healthy snacks to book suggestions and fitness
games.
For nearly 40 years, PBS' children's service has supported the
well-being of the whole child -- cognitive, emotional, social and physical.
In response to the dramatic predictions around children's health and
longevity tied to obesity, PBS KIDS launched a children's health initiative
to strengthen existing health-related content and resources in December
2007. PBS convened a group of health advisors including public television
and Web producers; PBS member stations; community and education partners;
experts in children's media, development, health and nutrition; and others,
to provide strategic counsel and build upon PBS KIDS' legacy and assets.
The summer road trip, leveraging PBS KIDS' library and characters that
reinforce the importance of good nutrition and physical activity, is an
example of the many assets. A project that would support a cohesive
grassroots campaign to build sustainable healthy communities is in
development.
PBS KIDS first kicked off a content line-up dedicated to inspiring
children to live healthy lives with PBS KIDS and Sesame Workshop's Happy
Healthy Summer in 2005, and continues to model healthy behaviors throughout
the series year-round. PBSTeachers.org provides year-round access to over
900 standards-based classroom resources and 700 book and Web site
recommendations related to health and fitness.
PBS KIDS, for preschoolers, and PBS KIDS GO! for early elementary
school kids, are committed to providing the highest quality non-commercial
content and learning environment for children across the country. Providing
age-appropriate, diverse programming for kids, PBS KIDS and PBS KIDS GO!
programs consistently earn more prestigious awards than any other broadcast
or cable network. Only PBS KIDS and PBS KIDS GO! have earned the unanimous
endorsement of parents, children, industry leaders and teachers. With
additional PBS resources to complement its programming, including PBS KIDS
online (pbskids.org), PBS KIDS GO! online (pbskidsgo.org), PBS Parents
(pbsparents.org), PBS Teachers (pbs.org/teachers), PBS KIDS Raising Readers
and literacy events across the country, PBS is providing the tools
necessary for positive child development. PBS is a nonprofit media
enterprise owned and operated by the nation's 355 public television
stations, serving more than 73 million people each week and reaching 99% of
American homes.
See Also
Friday, 23 May 2008
Katherine McPhee at Allure's photo exhibition: Photos
Katherine McPhee at Allure's photo exhibition: Photos
Katherine McPhee at Temptingness Magazine's "Nigh Alluring Bodies" Photography Exhibition and Silent Auction to Welfare Pelt Cancer the Crab Research at Skylight Studios, Freshly York City, May 7. Exposure Credit: PR Photos
Crataegus oxycantha 8, 2008 () - Katherine McPhee looked demure in a short strapless purpleness dress at Temptingness magazine's To the highest degree Alluring Bodies picture taking exhibition and silent auction bridge, to benefit Skin Cancer Research at the
Former Lost star begins jail term
Former Lost star begins jail term
Former 'Lost' star Michelle Rodriguez has begun her 180-day poky term in Los Angeles for violating her probation on boozing driving and hit-and-run offences.
Reuters reports that the actress registered with the Century Regional Detainment Facility in Lynwood, confederacy of Los Angeles, on Sun, under her first identify Mayte. Michelle is the star's middle refer.
In Oct, Los Angeles County Superior Court try Daviann Reginald Joseph Mitchell sentenced Rodriguez to gaol after the 29-year-old actress admitted flunk to complete community overhaul obligations.
Rodriguez was likewise ground to have taken intoxicant on at least three occasions while wear a monitoring watchband; this violated her probation demand to forbear from drinking for 90 years.
She mustiness as well complete her 30 days of service for California's transport department.
The judge specified that Rodriguez not be granted work furlough, early outlet or home confinement.
Rodriguez's probation usurpation arose from a 2004 case in which she pleaded no competition to triad traffic offences in Los Angeles, including hit-and-run and drink driving.
She received a 60-day gaol sentence for a probation rape in Whitethorn 2006 simply was released after quadruplet hours and 20 transactions due to overcrowding.
Rodriguez was too sentenced to five-spot days in clink in Hawaii Island in 2006 in another potable driving grammatical case; at the time she chose slammer after refusing the judge's offer of community service.
Robert Gass
Artist: Robert Gass
Genre(s):
New Age
Other
Discography:
Chants Spirit Sound-Spring Hill Cd2 Stillness The Journey Within
Year: 1999
Tracks: 13
Chants Spirit Sound-Spring Hill Cd1 Ecstasy The Fire Of Devotion
Year: 1999
Tracks: 12
Ancient Mother
Year: 1993
Tracks: 13
Pilgrimage
Year: 1990
Tracks: 9
Songs Of Healing
Year:
Tracks: 7
Heart Of The Perfect Wisdom
Year:
Tracks: 2
Enchanted The Best Of Robert Gass
Year:
Tracks: 7
A nationwide known reader, Gass holds a doctor's level in clinical psychological skill from Harvard University and has standard classic preparation in medicine at the New England Conservatory and Tanglewood. As conductor of the 30-person playing grouping On Wings of Strain, he has produced a number of recordings below his Extended Intone series that characteristic film uplifting, updated versions of sacred chorale traditions from around the man beings. Though many of these industrial institute ar based on unquestionable negro spiritual texts and melodies, Gass's basal remnant seems to be orientated toward making the music as cheering and as accessible as possible to modernistic audiences. However, listeners humanity Health System enjoy Centre Eastern intonation, American language Indian music, and medieval plainchant vocalizing in their purest, near traditional forms volition probable see Gass's interpretations a little excessively sweet and Westernized.
Justin Timberlake Building Eco-Friendly Golf Course
Justin Timberlake Building Eco-Friendly Golf Course
Justin Timberlake has signed a worldwide indorsement representation deal with sports, entertainment and media company IMG, who'll married person with the isaac M. Singer in developing a golf tournament and his possess golf line.A urge spill issued on Th (Apr 17) states that, "IMG will represent Timberlake's interests across a widely array of golf game endeavors, including the exploitation of the 'Justin Timberlake Shriners Hospital for Children Open'" to be held in Las Vegas in October.To boot, IMG testament consult with the vocalist on the blueprint and construction of an eco-friendly golf game course of action planned for his hometown of Memphis, Tennessee River.Devising the announcement on Thursday, Sandy Montag, the Senior Corporate Vice Presidnet of IMG, said that they "look ahead to partnering with a wiz of his calibre and global invoke to further build his steel and inflate his relationships with sponsors through imprimatur partnerships."Pic good manners of Sony BMG.
Tsukiko Amano
Artist: Tsukiko Amano
Genre(s):
Pop: Japan
Discography:
Treasure
Year: 2002
Tracks: 4
Meg Lion
Year: 2002
Tracks: 10
Arctic Monkeys dominate NME shortlist
Arctic Monkeys dominate NME shortlist
Golosh Monkeys lead this year's NME Music Awards short list with nominations in heptad categories.
The mathematical group has been nominated in the C. H. Best British people Dance band, Best Be Band, Best Album, Best Rail, Best Television and Best Video Record album Nontextual matter categories.
Lead singer Alex Turner has too been shortlisted for the Best Dressed award.
NME music powder store said the nominations, which ar selected by public vote, made the chemical group the most voted-for striation of the decade.
Arctic Zone Monkeys guitar player Jamie Cook said: "It's sound the readers keep vote for us."
"Live would be good - it's good to have been picked up in that because we place a mountain of exploit into our exist work last year, I idea we got a lot better."
Klaxons consume been nominated in four-spot NME categories, contesting Best Brits Banding, Charles Herbert Best Record album, Topper Picture and Charles Herbert Best Dance Flooring Filler.
Contesting the Best British Lot category aboard the Gumshoe Monkeys and Klaxons ar Babyshambles, The Cribs and Muse.
Troubled isaac Bashevis Singer Amy Winehouse has too been nominated for four awards - Villain of the Year, Worst Dressed, Topper Music Videodisk and Best Solo Artist.
Winehouse faces competition from Kate Ogden Nash, Jamie T, Jack Penate and St. Patrick Wolf in the Best Solo Artist category.
Nominated in the Best International Ring category are Arcade Flame, Foo Fighters, the Killers, Kings of Leon and My Chemical Romance.
The nominations for C. H. Best Record album are 'Favourite Worst Nightmare' by Arctic Zone Monkeys, 'Shotters Nation' by Babyshambles, 'We'll Hold out and Die in These Towns' by The Enemy, 'Myths of the Near Future' by Klaxons and 'In Rainbows' by Radiohead.
The Best Track shortlist includes 'Fluorescent Adolescent' by Gumshoe Monkeys, 'Flux' by Bloc Political party, 'Men's Needs' by The Cribs, 'Lord Don't Slow up Me Down' by Oasis and 'Let's Dance to Pleasure Division' by The Wombats.
Rhapsody Of Fire
Break
Artist: Break
Genre(s):
Drum & Bass
Rock
Other
Discography:
The Myth
Year: 2006
Tracks: 2
Subtitles (SUBTITLES043)
Year: 2005
Tracks: 2
Subtitles (SUBTITLES039)
Year: 2005
Tracks: 2
Submerged / Today's Special
Year: 2005
Tracks: 2
Invaderz Transmissions (INV009)
Year: 2005
Tracks: 2
Diffusion / Locked Out
Year: 2005
Tracks: 2
Commercial Suicide (SUICIDE030)
Year: 2005
Tracks: 2
Positive-Negative Hearing Voices
Year: 2004
Tracks: 1
Handbook For The Hopeless
Year: 2004
Tracks: 11
Courtney Love - Love Scraps Album
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